Thermostable single-stranded specific DNA binding protein from Thermus aquaticus, suitable for high temperature DNA manipulations. Helix destabilizing protein. Reduces formation of problematic secondary DNA structures. Prevents degradation of ssDNA by nucleases. Prevents inhibition of PCR by template DNA contaminants. Improves the efficiency of DNA amplification by Taq DNA Polymerase. Improves the specificity and selectivity of multiplex PCR. Aids PCR of difficult and GC-rich templates. Stabilizes single-stranded regions of DNA for site-specific mutagenesis. Aids completion of restriction enzyme digestion.